Fertility and Pregnancy Outcome after Treatment for Cancer in Childhood or Adolescence

Fertility and Pregnancy Outcome after Treatment for Cancer in Childhood or Adolescence.

Successful therapy for children and adolescents with cancer includes the use of ionizing irradiation and/or chemotherapeutic agents. These may produce DNA damage, resulting in cell death, or the damage may be sublethal. These effects may be expressed in the gonads as sterilization or germ cell DNA damage. Sterilization may be acute, or identified by the occurrence of premature menopause. DNA da...

Fertility Outcome after Operative Laparoscopy versus No Treatment in Infertile Women with Minimal or Mild Endometriosis

Fertility Outcome after Treatment of Unruptured Ectopic Pregnancy with Two Different Methotrexate Protocols

Fertility preservation and pregnancy outcome after malignancy.

PURPOSE OF REVIEW The overall survival and cure rates of patients with childhood and adult malignancies have improved dramatically, but cancer treatment can be associated with diminished reproductive potential. However, research on the preservation of fertility in these patients has given patients new options. This article discusses the mechanisms of reproductive failure after cancer therapy an...

Pregnancy outcome in female childhood cancer survivors.

BACKGROUND The number of childhood cancer survivors has dramatically increased and consequently, an increasing number of survivors may now wish to conceive. Recently, several studies have described that previous treatment with abdominal radiotherapy may increase the risk of adverse pregnancy outcome. METHODS We conducted a retrospective single centre cohort study of childhood cancer survivors...